現(xiàn)貨moradec AH-102-DD說明書
αHFc CL PNU
抗人IgG Fc-PNU159682抗體
目錄號：AH-102-DD
αHFc CL PNU是與PNU-159268結(jié)合的抗人IgG Fc特異性抗體，具有可裂解接頭?？贵w部分是對人IgG的Fc區(qū)特異的多克隆抗體。PNU-159682是內(nèi)柔比星的衍生物，是一種細(xì)胞毒性小分子，通過插入DNA和抑制復(fù)制導(dǎo)致細(xì)胞死亡。連接PNU-159682與抗體的可裂解接頭在細(xì)胞外液中是穩(wěn)定的，但一旦綴合物通過內(nèi)吞作用進(jìn)入細(xì)胞，則被內(nèi)體中的組織蛋白酶裂解。
| Anti-human IgG Fc-PNU159682 Antibody with Cleavable Linker | Catalog Number: AH-102-DD |
| αHFc-CL-PNU is anti-human IgG Fc specific antibody conjugated to PNU-159268 with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. PNU-159682, a derivative of nemorubicin, is a cytotoxic small molecule which causes cell death by intercalating DNA and inhibiting replication. The cleavable linker connecting PNU-159682 to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis. | |
